These young, immature red blood cells (reticulocytes) are only seen in high numbers when there is a reason for the body must produce extra red blood cells. As there is an increased demand on the bone marrow to make more cells, the new cells tend to be immature. As the body naturally produces more red blood cells in the bone marrow to compensate for a low hemoglobin level, many people with HS have mild anemia or no anemia at all. The symptoms of HS vary depending on the severity of the disease. The loss of RBCs causes the hemoglobin level in a patient to become low, possibly resulting in anemia. This results in a reduced number of RBCs in the body and can also cause the spleen to become enlarged. Often the spherocytes become damaged in the process of passing through the spleen and break apart in a process called hemolysis. The spleen is a filtering organ in the body. They are unable to change shape to pass through some of the organs and small blood vessels in the body as easily as normal red blood cells.īecause spherocytes can’t change their shape easily, they have a particularly difficult time passing through the spleen. These types of cells are called spherocytes (sphere-shaped RBC’s) and are more plump, round, and are not very flexible. The RBC’s in patients with HS can have a sphere-like shape. HS is a blood disorder in which the RBCs are misshapen and fragile. Hemoglobin is the part of the RBC that carries oxygen. Normal red blood cells look donut-shaped, they are flexible, sleek, and circulate easily through all of the body’s organs. It is the job of the red blood cells to circulate oxygen to all parts of the body. Red blood cells (RBCs) are an important part of your blood. In the United States, HS affects about 1 in 2,000 people of Northern European ancestry. If your child has HS, either parent may also have the disease however, in about 25% of cases, neither parent of an affected child has the disease. Hereditary spherocytosis (HS) is an inherited blood disease that results in anemia. Nurse Practitioners & Physician Assistants.Hematologic Eval for Surgery / Procedure.
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